- approaching Milano on the A7 motorway from Genova, the A1 motorway from Bologna or the A4 motorway from Turin: take the Tangenziale Ovest (westbound ring-road) northwards and follow the signs for 'fieramilano'
- approaching Milan on the A4 motorway from Venice towards Milan: take the 'Pero-fieramilano' exit
- approaching Milan on the A8 motorway from Varese and the A9 from Como/Chiasso: at the Milano Nord tollbooth, make for the A4 motorway to Venice, and take the 'fieramilano' exit
- leaving Milan on the A4 motorway towards Turin: take the 'Pero-fieramilano' exit .
- leaving Milan on the A8 motorway to Varese-Como: turn off at the 'fieramilano' exit
- from downtown Milan/Viale Certosa: continue along Via Gallarate then the SS 33 del Sempione highway and follow the signs for 'fieramilano'